Description
Product Characteristics:
Aliases: CD2 antigen binding protein 1 antibody, CD2 binding protein 1 antibody, CD2 cytoplasmic tail binding protein antibody, CD2-binding protein 1 antibody, CD2BP1 antibody, CD2BP1L antibody, CD2BP1S antibody, H PIP antibody, H-PIP antibody, HPIP antibody, PAPAS antibody, PEST phosphatase interacting protein 1 antibody, PEST phosphatase-interacting protein 1 antibody, PPIP1_HUMAN antibody, Proline serine threonine phosphatase interacting protein 1 antibody, Proline-serine-threonine phosphatase-interacting protein 1 antibody, PSTPIP antibody, Pstpip1 antibody
Target Information: The protein encoded by this gene binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. The encoded protein appears to be a scaffold protein and a regulator of the actin cytoskeleton. It has also been shown to bind ABL1, PTPN18, WAS, CD2AP, and PTPN12. Mutations in this gene are a cause of PAPA syndrome. [provided by RefSeq, Jul 2008]